2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-118815
    Lodinixil 86627-50-1 98%
    Lodinixil is a cholesterol inhibitor. Lodinixil can be used in research on endocrine and metabolic diseases such as hyperlipidemia.
    Lodinixil
  • HY-118945
    FR191413 194928-55-7 98%
    FR191413 is a selective bradykinin B2 receptor agonist that stimulates prostaglandin E2 production in WI-38 cells and activates BK B2 receptor-mediated pathways such as vasodilation and organ protection. FR191413 competitively binds to [3H]-BK in guinea pig ileum (GPI) membranes and CHO cells transfected with the human BK B2 receptor, with IC50 values ​​of 20.0 nM and 2.60 nM, respectively. FR191413 can be used in research related to cardiovascular diseases and diabetes, including hypertension, myocardial hypertrophy, myocardial infarction, arrhythmias, and diabetic nephropathy.
    FR191413
  • HY-119015
    MCHR1 antagonist 6 645399-82-2 98%
    MCHR1 antagonist 6 is a melanin-concentrating hormone receptor 1 (MCHR1) antagonist. MCHR1 antagonist 6 interacts with receptor residue D123 via its central basic group, and forms hydrogen bonds with receptor residue Q127 via its 2-amino-quinoline portion. MCHR1 antagonist 6 can be used for the research of obesity.
    MCHR1 antagonist 6
  • HY-119058
    ARI-809 463976-07-0 98%
    ARI-809 (CP-744809) is a highly selective, orally active aldose reductase inhibitor with an IC50 of 1 nM. ARI-809 blocks excessive glucose flux through the polyol pathway. ARI-809 normalizes elevated sorbitol and fructose levels in sciatic nerve tissues of diabetic rat models, inhibits sorbitol accumulation in lens tissues, and brings elevated urinary albumin excretion close to normal. ARI-809 can be used in diabetes research.
    ARI-809
  • HY-119059
    CU239 946249-82-7 98%
    CU239 is a potent and competitive non-retinoic acid inhibitor of RPE65 with an IC50 for RPE65 isomerase (11-cis retinal) of 6 μM. CCU239 exhibits delayed chromophore regeneration after light bleach, and conferrs a partial protection of the retina against injury from high intensity light. CU239 can be used for the study of retinal degeneration.
    CU239
  • HY-119119
    ATV399 393834-37-2 98%
    ATV399 is an inducible nitric oxide synthase (iNOS) inhibitor. ATV399 reduces NO production via allosteric inhibition of iNOS dimerization, thereby protecting rat pancreatic islet β-cells from cytokine-induced mitochondrial stress, endoplasmic reticulum stress, and apoptosis. ATV399 can be used in research related to type 1 diabetes.
    ATV399
  • HY-119164
    DC-S238 832109-48-5 98%
    DC-S238 is an orally active and highly selective histone methyltransferase SET7 (SETD7) inhibitor (IC50=4.88 μM). DC-S238 is promising for research of cancer, diabetes and inflammatory diseases.
    DC-S238
  • HY-119186
    Axillarin 5188-73-8 98%
    Axillarin is a natural flavonoid with anti-glycating and anti-oxidant effects.
    Axillarin
  • HY-119248
    KRP-297 213252-19-8 98%
    KRP-297 is a PPARα and PPARγ agonist potentially for the research of type 2 diabetes and dyslipidemia. KRP-297 restores reduced lipid oxidation, and inhibits of enhanced lipogenesis and triglyceride accumulation in the liver.
    KRP-297
  • HY-119395
    Kynuramine 363-36-0 98%
    Kynuramine is an endogenous amine that serves as a fluorescent substrate and probe for plasma amine oxidase.
    Kynuramine
  • HY-119436
    LG-120907 201654-12-8 98%
    LG-120907 is a selective androgen receptor (AR) antagonist with a Ki value of 26 nM. LG-120907 inhibits Testosterone-induced increases in ventral prostate (VP) tissue weight and seminal vesicles (SV) tissue weight in vivo.
    LG-120907
  • HY-119453
    Oxycinchophen 485-89-2 98%
    Oxycinchophen exhibits anti-inflammatory and uricosuric activity. Oxycinchophen displaces urate from albumin, exhibits high affinity for the DNSA-binding site on the albumin molecule.
    Oxycinchophen
  • HY-119524
    Clofibride 26717-47-5 98%
    Clofibride is an orally active hypolipaemic agent of pchlorophenoxyisobutyric type. Clofibride has weak toxicity and marked hypocholesterolaemic and hypotriglyceridaemic activity. Clofibride is converted into 4-chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) in vivo.
    Clofibride
  • HY-119593
    α-Homonojirimycin 119557-99-2 98%
    α-Homonojirimycin is a potent α-glucosidase inhibitor.
    α-Homonojirimycin
  • HY-119611
    Thioquinapiperifil 220060-39-9 98%
    Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study.
    Thioquinapiperifil
  • HY-119741
    Salacinol 200399-47-9 98%
    Salacinol, compound found in Salacia reticulata, is an orally active α-glucosidase/lipase inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC50 = 3.2 μg/mL, Ki = 0.31 μg/mL), sucrase (IC50 = 0.84 μg/mL, Ki = 0.32 μg/mL), and isomaltase (IC50 = 0.59 μg/mL, Ki = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus.
    Salacinol
  • HY-119858
    Acetiromate 2260-08-4 98%
    Acetiromate is a thyroxine analogue. Acetiromate is an antilipidemic drug for hyperlipidemia.
    Acetiromate
  • HY-119868
    Butaxamine 2922-20-5 98%
    Butaxamine (Butoxamin) is a potent, selective and orally active β2-adrenoceptor antagonist. Butaxamine shows antiosteoporotic activity.
    Butaxamine
  • HY-119875
    BMS-480404 533889-36-0 98%
    BMS-480404 is an inhibitor of keratinocyte fatty acid-binding protein (kFABP) and adipocyte lipid-binding protein (aP2). BMS-480404 has a Ki value of 33 nM for kFABP. BMS-480404 can be used in the research of metabolic disorders.
    BMS-480404
  • HY-119919
    Clofenamide 671-95-4 98%
    Clofenamide (Aquedux) is a carbonic anhydrase (CA) inhibitor. Clofenamide exhibits diuretic activity.
    Clofenamide
Cat. No. Product Name / Synonyms Application Reactivity